Both. Photoshop is the main program I use but with Painter you can do a few things differently and faster blending and pushing pixels around; like real paint so it's a bit more organic.
I just went and looked up the comics. I will now haunt my local comic book store until i have them all. There is just too much awesome to ignore them. O.O
After the comics you guys need to go right into the animation! Like how did these guys even meet up especially the fellow with the cane? Is he good/evil/neutral in this for his own gain? So many questions! MUST...READ....COMIC!!!!